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Physiological Change of Serum Bilirubin Level by ω-3 Enriched Parenteral Nutrition Versus ω-3 Free Parenteral Nutrition in Healthy Male Subjects
Surg Metab Nutr 2019;10(1):20-26
Published online June 30, 2019
© 2019 The Korean Society of Surgical Metabolism and Nutrition.

Mi Rin Lee, M.D., Ph.D.1, Min-Gul Kim, M.D., Ph.D.2,3,4, Jae Do Yang, M.D., Ph.D.1,4, Hong Pil Hwang, M.D., Ph.D.1,4, Yunjeong Kim, Ph.D.3,4, Ji-Young Jeon, Ph.D.3,4, Sungwoo Ahn, M.D.1,4, Hee Chul Yu, M.D., Ph.D.1,4,5

Departments of 1Surgery, 2Pharmacology, Chonbuk National University Medical School, 3Center for Clinical Pharmacology, Chonbuk National University Hospital, 4Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk University Hospital, 5Research Institute for Endocrine Sciences, Chonbuk National University, Jeonju, Korea
Correspondence to: Hee Chul Yu, Department of Surgery, Chonbuk National University Medical School, 20 Geonji-ro, Deokjin-gu, Jeonju 54907, Korea
Tel: +82-63-250-1576, Fax: +82-63-271-6197, E-mail:

This study was supported by JW Pharmaceutical, Corp., Seoul, Republic of Korea.
This article received the academic award in the 23th Fall Conference, Surgical metabolism and Nutrition, 2017.
Received April 15, 2019; Accepted June 5, 2019.
This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Purpose: Bilirubin is a biomarker for the diagnosis of liver diseases or bile duct dysfunction. This study assessed the physiological changes in the blood bilirubin level infusing ω-3 enriched parenteral nutrition (PN) and ω-3 free PN in healthy male subjects.
Materials and Methods: This study was a randomized, open-label, two-treatment, two-way crossover trial. Sixteen subjects were assigned randomly to one of two sequences of the two treatments: ω-3 enriched PN or ω-3 free PN was infused via aperipheral venous catheter for six hours at 3 mL/kg/h. Blood samples were collected every one hour from 0 to 12 hours after starting an intravenous infusion for bilirubin concentrations. The total bilirubin and direct bilirubin concentrations in the blood were analyzed using an enzymatic method.
Results: The bilirubin concentration in the blood was reduced while infusing the ω-3 enriched PN and ω-3 free PN. When it stopped infusing, the bilirubin concentration was recovered. A similar pattern was observed, but there was a further decline and recovery in ω-3 free PN.
Conclusion: When ω-3 enriched PN and ω-3 free PN are infused in healthy male subjects, the blood bilirubin level decreasedand there is no difference between the two groups.
Keywords : Parenteral nutrition, Omega-3, Bilirubin, Liver disease

June 2019, 10 (1)
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  • JW Pharmaceutical, Corp.